Key Peer Reviewed Journal Articles
Multivalent human antibody-centyrin fusion protein to prevent and treat Staphylococcus aureus infections. Buckley PT, Chan R, Fernandez J, Luo J, Lacey KA, DuMont AL, O’Malley A, Brezski RJ, Zheng S, Malia T, Whitaker B, Zwolak A, Payne A, Clark D, Sigg M, Lacy ER, Kornilova A, Kwok D, McCarthy S, Wu B, Morrow B, Nemeth-Seay J, Petley T, Wu S, Strohl WR, Lynch AS, Torres VJ.Cell Host Microbe. 2023 May 10;31(5):751-765.e11. doi: 10.1016/j.chom.2023.04.004. Epub 2023 Apr 24.PMID: 37098341
Cytoplasmic intron sequence-retaining transcripts can be dendritically targeted via ID element retrotransposons. Buckley PT, Lee MT, Sul JY, Miyashiro KY, Bell TJ, Fisher SA, Kim J, Eberwine J.Neuron. 2011 Mar 10;69(5):877-84. doi: 10.1016/j.neuron.2011.02.028.PMID: 21382548
Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. Sarau HM, Ames RS, Chambers J, Ellis C, Elshourbagy N, Foley JJ, Schmidt DB, Muccitelli RM, Jenkins O, Murdock PR, Herrity NC, Halsey W, Sathe G, Muir AI, Nuthulaganti P, Dytko GM, Buckley PT, Wilson S, Bergsma DJ, Hay DW. Mol Pharmacol. 1999 Sep;56(3):657-63.
Book Chapters
“RNA Binding Protein Methods” P.T. Buckley, J. Eberwine. 2009, In: Encyclopedia of Neuroscience (pp. 383-388), Larry R. Squire, Ed. Academic Press, Oxford.
“Genomics Approaches to the Study of Neurodegeneration” J. Jochems, P. Buckley, and J. Eberwine. 2008, In: Neural Degeneration and Repair (pp. 167-179), Hans Werner Müller, Ed. Wiley-VCH Verlag GmbH & Co. KGaA.
Additional Peer Reviewed Journal Articles
A single upstream mutation of whiB7 underlies amikacin and clarithromycin resistance in Mycobacterium abscessus.
De Boeck N, Villellas C, Crespo-Yuste E, Gonzalo-Asensio J, Buckley PT, Thys K, Vuong C, Lounis N, Verstraeten N, Michiels J.J Appl Microbiol. 2024 Nov 4;135(11):lxae286. doi: 10.1093/jambio/lxae286.PMID: 39537195
Staphylococcus aureus in Non-Cystic Fibrosis Bronchiectasis: Prevalence and Genomic Basis of High Inoculum β-Lactam Resistance. Mossman AK, Svishchuk J, Waddell BJM, Izydorczyk CS, Buckley PT, Hilliard JJ, Al-Ghalith G, Zheng L, Lynch AS, Mody CH, Lisboa LF, Gregson DB, Parkins MD.Ann Am Thorac Soc. 2022 Aug;19(8):1285-1293. doi: 10.1513/AnnalsATS.202108-965OC.PMID: 35213810
Identification of biologic agents to neutralize the bicomponent leukocidins of Staphylococcus aureus. Chan R, Buckley PT, O’Malley A, Sause WE, Alonzo F 3rd, Lubkin A, Boguslawski KM, Payne A, Fernandez J, Strohl WR, Whitaker B, Lynch AS, Torres VJ.Sci Transl Med. 2019 Jan 16;11(475):eaat0882. doi: 10.1126/scitranslmed.aat0882.PMID: 30651319
Transcriptome in vivo analysis (TIVA) of spatially defined single cells in live tissue. Lovatt D, Ruble BK, Lee J, Dueck H, Kim TK, Fisher S, Francis C, Spaethling JM, Wolf JA, Grady MS, Ulyanova AV, Yeldell SB, Griepenburg JC, Buckley PT, Kim J, Sul JY, Dmochowski IJ, Eberwine J.Nat Methods. 2014 Feb;11(2):190-6. doi: 10.1038/nmeth.2804. Epub 2014 Jan 12.PMID: 24412976
Serotonergic neuron regulation informed by in vivo single-cell transcriptomics. Spaethling JM, Piel D, Dueck H, Buckley PT, Morris JF, Fisher SA, Lee J, Sul JY, Kim J, Bartfai T, Beck SG, Eberwine JH.FASEB J. 2014 Feb;28(2):771-80. doi: 10.1096/fj.13-240267. Epub 2013 Nov 5.PMID: 24192459
Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers. Levin MD, Lu MM, Petrenko NB, Hawkins BJ, Gupta TH, Lang D, Buckley PT, Jochems J, Liu F, Spurney CF, Yuan LJ, Jacobson JT, Brown CB, Huang L, Beermann F, Margulies KB, Madesh M, Eberwine JH, Epstein JA, Patel VV. J Clin Invest. 2009 Nov;119(11):3420-36. doi: 10.1172/JCI39109. Epub 2009 Oct 12.
Insulin causes hyperthermia by direct inhibition of warm sensitive neurons. Sanchez-Alavez M, Tabarean IV, Osborn O, Mitsukawa K, Schaefer J, Dubins J, Holmberg KH, Klein I, Klaus J, Gomez LF, Kolb H, Secrest J, Jochems J, Myashiro K, Buckley P, Hadcock JR, Eberwine J, Conti B, Bartfai T. Diabetes. 2009 Oct 21. [Epub ahead of print]
The reduced folate carrier (SLC19A1) c.80G>A polymorphism is associated with red cell folate concentrations among women. Stanisławska-Sachadyn A, Mitchell LE, Woodside JV, Buckley PT, Kealey C, Young IS, Scott JM, Murray L, Boreham CA, McNulty H, Strain JJ, Whitehead AS. Ann Hum Genet. 2009 Sep;73(Pt 5):484-91. Epub 2009 Jul 28.
Discovery of (3-endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide as an efficacious inhaled muscarinic acetylcholine receptor antagonist for the treatment of COPD. Wan Z, Laine DI, Yan H, Zhu C, Widdowson KL, Buckley PT, Burman M, Foley JJ, Sarau HM, Schmidt DB, Webb EF, Belmonte KE, Palovich M. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4560-2. Epub 2009 Jul 8.
Transcriptome transfer produces a predictable cellular phenotype. Sul JY, Wu CW, Zeng F, Jochems J, Lee MT, Kim TK, Peritz T, Buckley P, Cappelleri DJ, Maronski M, Kim M, Kumar V, Meaney D, Kim J, Eberwine J. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7624-9. Epub 2009 Apr 20.
Cytoplasmic BK(Ca) channel intron-containing mRNAs contribute to the intrinsic excitability of hippocampal neurons. Bell TJ, Miyashiro KY, Sul JY, McCullough R, Buckley PT, Jochems J, Meaney DF, Haydon P, Cantor C, Parsons TD, Eberwine J. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1901-6. Epub 2008 Feb 4.
HIV-1 Viral protein-r (Vpr) protects against lethal superantigen challenge while maintaining homeostatic T cell levels in vivo. Muthumani K, Choo AY, Hwang DS, Dayes NS, Chattergoon M, Mayilvahanan S, Thieu KP, Buckley PT, Emmanuel J, Premkumar A, Weiner DB. Mol Ther. 2005 Nov;12(5):910-21. Epub 2005 Jul 11.
Nonpeptidic urotensin-II receptor antagonists I: in vitro pharmacological characterization of SB-706375. Douglas SA, Behm DJ, Aiyar NV, Naselsky D, Disa J, Brooks DP, Ohlstein EH, Gleason JG, Sarau HM, Foley JJ, Buckley PT, Schmidt DB, Wixted WE, Widdowson K, Riley G, Jin J, Gallagher TF, Schmidt SJ, Ridgers L, Christmann LT, Keenan RM, Knight SD, Dhanak D. Br J Pharmacol. 2005 Jul;145(5):620-35.
Cloning and pharmacological characterization of the cat urotensin-II receptor (UT). Aiyar N, Johns DG, Ao Z, Disa J, Behm DJ, Foley JJ, Buckley PT, Sarau HM, van-der-Keyl HK, Elshourbagy NA, Douglas SA. Biochem Pharmacol. 2005 Apr 1;69(7):1069-79.
A coding polymorphism in the CYSLT2 receptor with reduced affinity to LTD4 is associated with asthma. Pillai SG, Cousens DJ, Barnes AA, Buckley PT, Chiano MN, Hosking LK, Cameron LA, Fling ME, Foley JJ, Green A, Sarau HM, Schmidt DB, Sprankle CS, Blumenthal MN, Vestbo J, Kennedy-Wilson K, Wixted WE, Wagner MJ, Anderson WH, Ignar DM; Investigators of the GAIN Network. Pharmacogenetics. 2004 Sep;14(9):627-33.
Radioligand binding and functional characterization of recombinant human NmU1 and NmU2 receptors stably expressed in clonal human embryonic kidney-293 cells. Aiyar N, Disa J, Foley JJ, Buckley PT, Wixted WE, Pullen M, Shabon U, Dul E, Szekeres PG, Elshourbagy NA, Sarau HM, Appelbaum E, Bolaky J. Pharmacology. 2004 Sep;72(1):33-41.
Regulation of TNF-alpha- and IFN-gamma-induced CXCL10 expression: participation of the airway smooth muscle in the pulmonary inflammatory response in chronic obstructive pulmonary disease. Hardaker EL, Bacon AM, Carlson K, Roshak AK, Foley JJ, Schmidt DB, Buckley PT, Comegys M, Panettieri RA Jr, Sarau HM, Belmonte KE. FASEB J. 2004 Jan;18(1):191-3. Epub 2003 Nov 3.
A potent and selective nonpeptide antagonist of CXCR2 inhibits acute and chronic models of arthritis in the rabbit. Podolin PL, Bolognese BJ, Foley JJ, Schmidt DB, Buckley PT, Widdowson KL, Jin Q, White JR, Lee JM, Goodman RB, Hagen TR, Kajikawa O, Marshall LA, Hay DW, Sarau HM. J Immunol. 2002 Dec 1;169(11):6435-44.
Molecular and pharmacological characterization of the murine tachykinin NK(3) receptor. Sarau HM, Feild JA, Ames RS, Foley JJ, Nuthulaganti P, Schmidt DB, Buckley PT, Elshourbagy NA, Brawner ME, Luttmann MA, Giardina GA, Hay DW. Eur J Pharmacol. 2001 Feb 16;413(2-3):143-50.
Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor. Elshourbagy NA, Ames RS, Fitzgerald LR, Foley JJ, Chambers JK, Szekeres PG, Evans NA, Schmidt DB, Buckley PT, Dytko GM, Murdock PR, Milligan G, Groarke DA, Tan KB, Shabon U, Nuthulaganti P, Wang DY, Wilson S, Bergsma DJ, Sarau HM. J Biol Chem. 2000 Aug 25;275(34):25965-71.
Original Abstracts
Buckley, P.T., Lee, M., Sul, J., Miyashiro, K., Bell, T., Fisher, S., Kim, J., Eberwine, J. Retention of specific intronic sequences is an important feature of post-transcriptional mRNA regulation in neuronal dendrites. American Society for Cell Biology Annual Meeting, Dec 2009, San Diego, CA.
Buckley, P.T., Lee, M., Bell, T., Miyashiro, K., Sul, J., Kim, J., Eberwine, J. Single Cell mRNA Analysis: RNA drives Cellular Phenotype and Functionality of mRNA containing Retained Introns in Neurons. American Society for Cell Biology Annual Meeting, Dec 2009, San Diego, CA.
Bell, T.J., Miyashiro, K.Y., Buckley, P.T., Eberwine, J. Splice variant-specific intron retention facilitates the structural diversity of BKCa channel mRNAs and proteins. Society for Neuroscience Annual Meeting, Oct 2009, Chicago, IL.
Francis, C., Buckley, P.T., Fisher, S. A., Lee, M. T., Sul, J.-Y., Gawlas, I., Guest, J., Eberwine, J. H., Kim, J. Evolution of molecular physiology in mammalian neurons. Society for Neuroscience Annual Meeting, Oct 2009, Chicago, IL.
Ross, J.R., Porter, B.E., Buckley, P.T., Eberwine, J. H., Robinson, M.B. Dramatic increases in dendritic targeting and mGluR-regulated translation of mRNA for the EAAC1 subtype of neuronal glutamate transporter after a seizure. Society for Neuroscience Annual Meeting, Oct 2009, Chicago, IL.
Bell, T.J., Miyashiro, K.Y., Sul, J.-Y., Buckley, P.T., McCullough R., Cantor, C., Parsons, T.D., Eberwine, J. Structure, function, and regulation analysis of cytoplasmic intron-containing BKCa channel mRNAs in hippocampal neurons. Society for Neuroscience Annual Meeting, Nov 2008, Washington, DC.
Klein, I., Osborn, O., Tabarean, I., Sanchez-Alvarez, M., Gregorsson, E., Ross, B., Conti, B., Jochems, J., Buckley, P., Eberwine, J., Loging, W., Hadcock, J., Bartfai, T. Characterization of single warm sensitive hypothalamic neurons. Society for Neuroscience Annual Meeting, Nov 2008, Washington, DC.
Bell, T.J., Miyashiro, K.Y., Sul, J., Buckley, P., Jochems, J., Parsons, T., Eberwine, J. Cytoplasmic BKCa channel intron-containing mRNAs contribute to the intrinsic excitability and BK channel protein distribution in hippocampal neurons. Society for Neuroscience Annual Meeting, Nov 2007, San Diego, CA.
Ross, J.R., Porter, B.E., Buckley, P.T., Eberwine, J. H., Robinson, M.B. The glutamate transporter, excitatory amino acid carrier 1 (EAAC1) mRNA is found in hippocampal dendrites and its translation may be locally controlled. Society for Neuroscience Annual Meeting, Nov 2007, San Diego, CA.
Wang, Y., Wang, F., Vinader, V.M., Hancock, A.P., Kerns, J.K., Morrow, D.M., Rao, P., Nguyen, C., Barrett, V.J., Browning, C., Hartmann, G., Andrew, D.P., Sarau, H.M., Foley, J.J., Schmidt, D.B., Buckley, P.T., Burman, M., Jurewicz, A.J., Fornwald, J.A., Wang, B., Moore, M.L., Rivero, R.A., Belmonte, K.E., Connor, H.E., Jin, J. Oxazolidinones as novel human CCR8 antagonists. National Medicinal Chemistry Symposium, Jun 2006, Seattle, WA.
Herold, C.L., Behm, D.J., Buckley, P.T., Foley, J.J., Douglas, S.A. The peptidic somatostatin analogs lanreotide, BIM-23127, and BIM-23042 are urotensin-II receptor ligands. Mid-Atlantic Pharmacology Society Annual Meeting, Sep 2002, Wilmington, DE.
Ames, R.S., Sarau, H.M., Chambers, J.K., Foley, J.J., Buckley, P.T., Schmidt, D.B., Tornetta, M., Rao, P., Levy, D., Slemmon, R., Wu, Z., King, A., Dally, J., LePage, C., Behm, D., Burns, M., Wilson, S., Muir, S., Szekeres, P.G., Evans, N., Fitzgerald, L., Dytko, G., Rice, K., Vawter, L., Gattu, N., Ellis, C.E., Lane, P., Tsui, P., Elshourgbagy, N.A., Shabon, U., Debouck, C., Bergsma, D.J. Orphan GPCR functional genomics: trials and tribulations of assay development. MDC International Drug Discovery Conference, 2001, Lake Tahoe, NV.
Szekeres, P.G., Spinage, L., Butler, S., Smith, A., Muir, A., Middleton, S., Thompson, C., Ames, R.S., Sarau, H.M., Foley, J.J., Buckley, P.T., Rao, P., Chambers, J.K., Evans, N., Tornetta, M., Hill, J., Franks, A., McLaughlin, M., Guy, A., Elshourbagy, N.A., Shabon, U., Rice, K., Vawter, L., Gattu, N., Duckworth, M., Wilson, S., Bergsma, D.J. Deorphanization of human 7TM receptors using FLIPR success stories, pitfalls and potential solutions. MDC International Drug Discovery Conference, 2001, Lake Tahoe, NV.
Ames, R.S., Sarau, H.M., Chambers, J.K., Foley, J.J., Buckley, P.T., Schmidt, D.B., Tornetta, M., Rao, P., Levy, D., Slemmon, R., Wu, Z., King, A., Dally, J., LePage, C., Behm, D., Burns, M., Wilson, S., Muir, S., Szekeres, P.G., Evans, N., Fitzgerald, L., Dytko, G., Rice, K., Vawter, L., Gattu, N., Ellis, C.E., Lane, P., Tsui, P., Elshourgbagy, N.A., Shabon, U., Debouck, C., Bergsma, D.J. FLIPR: A platform for orphan G-protein coupled receptor functional genomics. MDC International Drug Discovery Conference, 2000, Monterey, CA.